TRAIL-R1

TRAIL-R1 (also known as DR4) is a protein that in humans is encoded by the TRAILR1 gene. It is a cell surface receptor that is a member of the tumor necrosis factor receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), leading to apoptosis.

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis but has been shown to play a role in the inhibition of TRAIL-induced cell death.

Clinical significance

TRAIL-R1 has been shown to interact with TRAIL, a cytokine that induces apoptosis. This interaction is thought to play a role in cancer cell death and has been exploited in therapeutic strategies against cancer.

Interactions

TRAIL-R1 has been shown to interact with:

• TRAIL
• FADD
• Caspase 8
• Caspase 10

See also

• TRAIL
• TRAIL-R2
• TRAIL-R3
• TRAIL-R4

External links

• GeneReviews/NCBI/NIH/UW entry on TRAIL-R1

TRAIL-R1 Resources
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