TRAIL-R1
TRAIL-R1 (also known as DR4) is a protein that in humans is encoded by the TRAILR1 gene. It is a cell surface receptor that is a member of the tumor necrosis factor receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), leading to apoptosis.
Function[edit | edit source]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis but has been shown to play a role in the inhibition of TRAIL-induced cell death.
Clinical significance[edit | edit source]
TRAIL-R1 has been shown to interact with TRAIL, a cytokine that induces apoptosis. This interaction is thought to play a role in cancer cell death and has been exploited in therapeutic strategies against cancer.
Interactions[edit | edit source]
TRAIL-R1 has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
