Death receptor 4

Death receptor 4 (DR4) is a protein that in humans is encoded by the TNFRSF10A gene. It is a member of the tumor necrosis factor receptor superfamily, and is also known as TRAIL receptor 1 (TRAILR1) and TNF-related apoptosis-inducing ligand receptor 1.

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Clinical significance

Mutations in the TNFRSF10A gene have been associated with various forms of cancer, including lung cancer, breast cancer, and colorectal cancer. The protein is also involved in immune system regulation and may play a role in autoimmune diseases.

Interactions

Death receptor 4 has been shown to interact with:

• FADD,
• CFLAR, and
• CASP8.

See also

• TNF receptor
• Apoptosis
• Tumor necrosis factor

External links

• WikiMD Article on Death receptor 4