Tachykinin

Tachykinin is a family of peptides that are known to be involved in functions of the nervous system, cardiovascular system, immune system, and digestive system. The tachykinin peptide family includes substance P, neurokinin A, neurokinin B, and neuropeptide K.

Function

Tachykinins are known to have a wide range of effects in the body. They are involved in the regulation of blood pressure, pain perception, and inflammation. They also play a role in the regulation of mood and anxiety.

Structure

Tachykinins are characterized by a common amino acid sequence at the C-terminal end. This sequence is responsible for their biological activity. The tachykinins are synthesized as large precursor proteins, which are then cleaved to produce the active peptides.

Receptors

Tachykinins exert their effects by binding to specific receptors on the surface of cells. There are three known types of tachykinin receptors, named NK1, NK2, and NK3. Each of these receptors has a different affinity for the various tachykinins.

Clinical significance

Tachykinins and their receptors have been implicated in a number of diseases, including asthma, irritable bowel syndrome, depression, and migraine. Drugs that block the action of tachykinins are being developed as potential treatments for these conditions.

See also

• Neuropeptide
• Neurotransmitter
• G protein-coupled receptor

Tachykinin Resources
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