Liothyronine

Overview of the use of Liothyronine in medical treatment

Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (T3) and is used in the treatment of hypothyroidism and certain other medical conditions. It is known for its rapid onset of action and is often used when a quick response is desired.

Medical Uses

Liothyronine is primarily used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormones. It is also used in the treatment of myxedema coma, a severe form of hypothyroidism that requires immediate medical attention. Additionally, liothyronine may be used in diagnostic tests for thyroid function and as an adjunct therapy in the treatment of certain types of thyroid cancer.

Mechanism of Action

Liothyronine works by replacing or supplementing the natural thyroid hormones in the body. It increases the basal metabolic rate, affects protein synthesis, and increases the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. It is more potent and has a faster onset of action compared to levothyroxine, another commonly used thyroid hormone replacement.

Dosage and Administration

Liothyronine is available in tablet form and is usually taken orally. The dosage of liothyronine is individualized based on the patient's age, weight, cardiovascular status, and the specific condition being treated. It is important to monitor thyroid function tests regularly to adjust the dosage as needed.

Side Effects

Common side effects of liothyronine include symptoms of hyperthyroidism such as increased heart rate, anxiety, weight loss, and insomnia. In rare cases, it can cause more serious side effects such as atrial fibrillation or osteoporosis with long-term use.

Contraindications

Liothyronine is contraindicated in patients with uncorrected adrenal insufficiency and in those with untreated thyrotoxicosis. Caution is advised in patients with cardiovascular disease due to the risk of exacerbating these conditions.

Interactions

Liothyronine can interact with several medications, including anticoagulants, insulin, and oral hypoglycemic agents. It can also affect the efficacy of digitalis glycosides and may require dosage adjustments of these medications.

Also see

• Hypothyroidism
• Thyroid hormone
• Levothyroxine
• Thyroid cancer