TrkC

TrkC is a protein that in humans is encoded by the NTRK3 gene. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. TrkC has been shown to interact with NTF3 and NGFR.

Function

TrkC is the high affinity catalytic receptor for the neurotrophin NT-3. Thus, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.

Clinical significance

Mutations in TrkC gene resulting in a truncated TrkC receptor lacking the intracellular kinase domain, have been associated with congenital insensitivity to pain with anhidrosis (CIPA). CIPA is a rare disorder characterized by the inability to feel pain and temperature, and decreased or absent sweating.

Interactions

TrkC has been shown to interact with:

• Neurotrophin-3
• NGFR

See also

• Tropomyosin receptor kinase C
• NTRK3

External links

• NTRK3 at the US National Library of Medicine Medical Subject Headings (MeSH)

TrkC Resources
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Further reading

• "TrkC, a receptor for neurotrophin-3, is widely expressed in the developing chicken embryo."
• "The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm."