Trunk neural crest

Trunk Neural Crest

File:Neural crest cells.svg

Illustration of neural crest cells. The trunk neural crest is a specific type of these cells.

The Trunk Neural Crest refers to a group of neural crest cells that migrate from the neural tube during the embryonic development of vertebrates. These cells are unique in their multipotency, capable of differentiating into a variety of cell types, including neurons, glial cells, melanocytes, and adrenal medulla cells.

Development

File:Neural crest migration paths.svg

Diagram showing the migration paths of neural crest cells, including the trunk neural crest.

During embryogenesis, the trunk neural crest cells emerge from the dorsal neural tube and migrate ventrally. They follow specific pathways, guided by a combination of chemotaxis, haptotaxis, and mechanotaxis. The cells differentiate into various cell types depending on their final location.

Function

The trunk neural crest cells play a crucial role in the formation of the peripheral nervous system. They give rise to the dorsal root ganglia, which contain the cell bodies of sensory neurons. They also contribute to the formation of the sympathetic nervous system, producing the sympathetic ganglia and the adrenal medulla.

Clinical Significance

Abnormalities in the development or migration of trunk neural crest cells can lead to a variety of congenital disorders, including Hirschsprung's disease, neuroblastoma, and Waardenburg syndrome.

Research

Research into the trunk neural crest has provided valuable insights into the mechanisms of cell migration, differentiation, and the development of the nervous system. It also has potential implications for the treatment of diseases such as cancer and neurodegenerative diseases.

See Also

• Neural crest
• Neural tube
• Embryogenesis
• Congenital disorders