Tuberculin
(Redirected from Tuberculin purified protein derivative)
Tuberculin, also known as Purified Protein Derivative (PPD), is a substance used in the diagnosis of tuberculosis (TB). It is a mixture of proteins that are extracted from the bacterium Mycobacterium tuberculosis, the causative agent of TB.
History[edit | edit source]
Tuberculin was first developed by Robert Koch in 1890. Koch originally believed that tuberculin could be used as a therapeutic agent to treat TB, but it was later found to be ineffective for this purpose. However, it was discovered that tuberculin could be used as a diagnostic tool to detect a TB infection.
Use in Tuberculosis Testing[edit | edit source]
Tuberculin is used in the Tuberculin skin test, also known as the Mantoux test. In this test, a small amount of tuberculin is injected under the skin. If a person has been infected with TB, their immune system will react to the tuberculin, causing a raised, hard bump or swelling at the site of the injection.
Preparation[edit | edit source]
Tuberculin is prepared by growing Mycobacterium tuberculosis in a liquid medium, then heat-killing the bacteria and harvesting the proteins. The proteins are then purified to remove any contaminants.
Side Effects[edit | edit source]
Possible side effects of the tuberculin skin test include pain and redness at the injection site. In rare cases, a severe allergic reaction may occur.
See Also[edit | edit source]
Tuberculin Resources | ||
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