BRAF (gene)
(Redirected from V-raf murine sarcoma viral oncogene homolog B1)
BRAF Gene and B-Raf Protein[edit | edit source]
The BRAF gene is a human gene responsible for encoding the B-Raf protein, an enzyme involved in intracellular signaling. It plays a key role in cell growth and development and has been linked to various cancers and some birth defects.
Gene and Protein Overview[edit | edit source]
BRAF, also known as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, encodes the serine/threonine-protein kinase B-Raf protein. This protein is a part of the RAF/MAP kinase signaling cascade, a pathway critical for cell division and differentiation.
Role in Cell Signaling[edit | edit source]
B-Raf is a key player in the MAPK/ERK signaling pathway, which regulates cell growth and division. Alterations in this pathway can lead to uncontrolled cell proliferation.
Significance in Cancer[edit | edit source]
In 2002, mutations in the BRAF gene were discovered to be involved in various human cancers, including melanoma, colorectal cancer, and others. These mutations lead to an overactive B-Raf protein, contributing to cancer development.
Mutations and Birth Defects[edit | edit source]
Certain inherited mutations of the BRAF gene are implicated in congenital disorders. These mutations can disrupt normal development, leading to birth defects.
External Links[edit | edit source]
BRAF (gene) Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Kondreddy Naveen