Amphetamine aspartate

Amphetamine Aspartate is a pharmacological compound used primarily in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and Narcolepsy. It is one of the four salts that comprise the mixed amphetamine salts (MAS), which is more commonly known under the brand name Adderall. Amphetamine aspartate functions as a central nervous system (CNS) stimulant, promoting increased attention, focus, and wakefulness in individuals diagnosed with these conditions.

Chemistry

Amphetamine aspartate is an amphetamine salt, where the amphetamine base is combined with aspartic acid. This combination enhances the drug's solubility and absorption when ingested. The molecular formula for amphetamine aspartate monohydrate is C11H17N2O8, indicating the presence of a single water molecule in its crystalline form.

Pharmacology

The mechanism of action of amphetamine aspartate involves the increased release of the neurotransmitters dopamine and norepinephrine in the brain, particularly in areas associated with attention and alertness. This action is achieved by reversing the transport direction of the monoamine transporters, leading to an efflux of these neurotransmitters from the synaptic vesicles to the synaptic cleft. Additionally, amphetamine aspartate inhibits the action of monoamine oxidase (MAO), an enzyme responsible for the breakdown of dopamine and norepinephrine, further increasing their availability in the brain.

Medical Uses

Amphetamine aspartate, as part of mixed amphetamine salts, is primarily prescribed for the treatment of ADHD. It helps to reduce symptoms such as hyperactivity, impulsivity, and inattention. It is also used in the management of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks.

Side Effects

Common side effects of amphetamine aspartate include insomnia, decreased appetite, weight loss, increased heart rate, and anxiety. More severe side effects may include cardiovascular events, psychiatric disorders such as psychosis, and potential for abuse and dependence. Its use is contraindicated in individuals with a history of substance abuse or certain cardiovascular conditions.

Regulation

Due to its potential for abuse and dependence, amphetamine aspartate is classified as a Schedule II controlled substance in the United States under the Controlled Substances Act. This classification requires strict regulation of its prescription and dispensation.

See Also

• Adderall
• Attention Deficit Hyperactivity Disorder (ADHD)
• Narcolepsy
• Central Nervous System Stimulants
• Dopamine
• Norepinephrine