Transvection

Transvection is a term used in genetics to describe a mechanism of gene regulation in Drosophila. It involves the interaction between an allele on one chromosome and the corresponding allele on the homologous chromosome. This interaction can result in either an increase or decrease in the level of gene expression.

Mechanism

Transvection is thought to occur through a process known as chromosome pairing, where homologous chromosomes align with each other in the nucleus. This pairing allows regulatory elements, such as enhancers, on one chromosome to interact with the corresponding gene on the other chromosome.

In some cases, transvection can result in the activation of a gene that is normally silent. This is known as enhancer-mediated transvection. In other cases, transvection can result in the silencing of a gene that is normally active. This is known as silencer-mediated transvection.

Role in Disease

While transvection has been most extensively studied in Drosophila, it is thought to occur in other organisms as well, including humans. There is evidence to suggest that transvection may play a role in certain diseases, such as cancer, by disrupting normal gene regulation.

See Also

• Gene regulation
• Chromosome pairing
• Enhancer (genetics)
• Silencer (genetics)

References

Transvection Resources
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