Gamma delta T cell
(Redirected from Γδ T-cells)
Gamma delta T cells are a small subset of T cells that possess a distinct T cell receptor (TCR) on their surface. Most T cells are alpha-beta (αβ) T cells with TCR composed of an alpha (α) chain and a beta (β) chain. Unlike αβ T cells, γδ T cells are able to recognize non-peptidic antigens without the need for antigen presenting cells.
Etymology[edit | edit source]
The name "Gamma delta T cells" comes from the type of T cell receptor (TCR) they express on their cell surface. This TCR is made up of one gamma (γ) chain and one delta (δ) chain, which is different from the alpha (α) and beta (β) chain found on most T cells.
Function[edit | edit source]
Gamma delta T cells are primarily found in the gut mucosa, where they are believed to contribute to immune responses. They are particularly effective at fighting certain types of infections, including those caused by Mycobacteria and Listeria, and may also play a role in autoimmune diseases.
Related Terms[edit | edit source]
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD