Γ-Acetylenic-GABA
0Γ-Acetylenic-GABA (also known as GAG) is a neurotransmitter inhibitor that specifically targets the GABA transaminase enzyme. It is a derivative of the naturally occurring neurotransmitter gamma-aminobutyric acid (GABA), and is used in scientific research to understand the role of GABA in the nervous system.
Structure and Function[edit | edit source]
Γ-Acetylenic-GABA is a structural analog of GABA, meaning it shares a similar structure but has different chemical properties. The key difference is the presence of an acetylenic group (a carbon-carbon triple bond) in the gamma position of the molecule. This modification allows Γ-Acetylenic-GABA to inhibit the action of GABA transaminase, an enzyme that breaks down GABA in the body.
By inhibiting GABA transaminase, Γ-Acetylenic-GABA increases the concentration of GABA in the brain. This can have a variety of effects, as GABA is a major inhibitory neurotransmitter and plays a key role in many neurological processes, including neural development, synaptic plasticity, and the regulation of sleep and mood.
Uses in Research[edit | edit source]
Γ-Acetylenic-GABA is primarily used in scientific research to study the role of GABA in the nervous system. By increasing the concentration of GABA, researchers can observe the effects of this neurotransmitter on various neurological processes and conditions.
For example, Γ-Acetylenic-GABA has been used to study the role of GABA in epilepsy, a neurological disorder characterized by recurrent seizures. By increasing the concentration of GABA, Γ-Acetylenic-GABA can help to reduce the frequency and severity of seizures, providing valuable insights into the potential therapeutic uses of GABA for this condition.
Safety and Side Effects[edit | edit source]
As a research chemical, Γ-Acetylenic-GABA is not intended for human consumption. However, studies in animals have shown that it can cause side effects such as sedation and motor impairment, likely due to its effects on GABA levels in the brain.
See Also[edit | edit source]
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