Κ-bungarotoxin
Κ-bungarotoxin is a neurotoxin derived from the venom of the Many-banded krait snake. It is a member of the Bungarotoxins family, which are potent neurotoxins that interfere with nerve signal transmission.
Structure and Function[edit | edit source]
Κ-bungarotoxin is a protein composed of two chains, A and B, linked by disulfide bonds. The A chain is responsible for the toxin's lethal effects, while the B chain facilitates the toxin's entry into cells. The toxin works by binding to the nicotinic acetylcholine receptor at the neuromuscular junction, blocking the action of acetylcholine, a neurotransmitter that signals muscles to contract. This results in paralysis and can lead to death due to respiratory failure.
Clinical Significance[edit | edit source]
Κ-bungarotoxin is of significant interest in neuroscience and pharmacology due to its ability to selectively bind to nicotinic acetylcholine receptors. This makes it a useful tool for studying these receptors and their role in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and myasthenia gravis. In addition, understanding the structure and function of Κ-bungarotoxin could potentially lead to the development of new drugs for treating these and other conditions.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
