RTI-55

RTI-55 (also known as 2β-carbomethoxy-3β-(4-iodophenyl)tropane or β-CIT) is a synthetic compound of the phenyltropane group. It is used in scientific research and has been studied for potential use in medical imaging. RTI-55 binds to the dopamine transporter (DAT) and the serotonin transporter (SERT), and to a lesser extent the norepinephrine transporter (NET).

Etymology

The name "RTI-55" is derived from the initials of the Research Triangle Institute, which first synthesized the compound, and the number 55, which is the order in which it was synthesized.

Pharmacology

RTI-55 is a potent inhibitor of the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). It has been used in scientific research to map the distribution of these transporters in the brain. RTI-55 is radiolabeled with iodine-123 for this purpose.

Medical Imaging

RTI-55 has been studied for potential use in medical imaging. It can be used to label the dopamine transporter in the brain, which may be useful in the diagnosis of Parkinson's disease and other disorders of the dopaminergic system.

Related Compounds

RTI-55 is a member of the phenyltropane group of compounds, which also includes RTI-31, RTI-32, RTI-51, and RTI-121. These compounds are all potent inhibitors of the dopamine transporter.

See Also

• Phenyltropane
• Dopamine transporter
• Serotonin transporter
• Norepinephrine transporter

RTI-55 Resources
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