(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid[edit | edit source]
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid is a chemical compound that acts as a selective antagonist of the GABAC receptor. It is commonly abbreviated as TPMPA.
Chemical Structure[edit | edit source]
The chemical structure of (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid consists of a tetrahydropyridine ring attached to a methylphosphinic acid group. The presence of the phosphinic acid moiety is crucial for its activity as a GABAC receptor antagonist.
Mechanism of Action[edit | edit source]
TPMPA functions by selectively inhibiting the GABAC receptors, which are a subclass of GABA receptors. These receptors are ligand-gated ion channels that mediate inhibitory neurotransmission in the central nervous system. By blocking these receptors, TPMPA can modulate the inhibitory effects of GABA, potentially affecting various neurological processes.
Applications in Research[edit | edit source]
Due to its selective antagonistic properties, TPMPA is used in neuroscience research to study the role of GABAC receptors in the brain. It helps in understanding the physiological and pathological roles of these receptors in various neurological conditions.
Related Compounds[edit | edit source]
TPMPA is part of a broader class of compounds known as GABA receptor antagonists. Other related compounds include bicuculline and picrotoxin, which target different subtypes of GABA receptors.
See Also[edit | edit source]
Related Pages[edit | edit source]
Structure of (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid
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Contributors: Prab R. Tumpati, MD
