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What is 1,4,6-Androstatriene-3,17-dione?[edit | edit source]

  • Androsta-1,4,6-triene-3,17-dione is an androstanoid that is androsta-1,4,6-triene substituted by oxo groups at positions 3 and 17.
  • It is a 17-oxo steroid, an androstanoid and a 3-oxo-Delta(1),Delta(4)-steroid.
  • IUPAC Name: (8R,9S,10R,13S,14S)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-3,17-dione
  • InChI: InChI=1S/C19H22O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3-4,7,9,11,14-16H,5-6,8,10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
  • Canonical SMILES: CC12CCC3C(C1CCC2=O)C=CC4=CC(=O)C=CC34C
  • Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)C=CC4=CC(=O)C=C[C@]34C
  • Molecular formula: C19H22O2
  • Molecular weight: 282.4 g·mol−1
  • Synonyms:
  1. Androsta-1,4,6-triene-3,17-dione
  2. 633-35-2
  3. 1,4,6-Androstatrien-3,17-dione
  4. 1,4,6-Etioallochan-dione
  5. UNII-217A6T1V8N
  6. CHEMBL2311178
  7. 217A6T1V8N
  8. (8R,9S,10R,13S,14S)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-3,17-dione
  9. 1,4,6-Andorstatriene-3,17-dione
  10. A146-T317D
  11. ATD
  12. SCHEMBL132874
  13. DTXSID60862328
  14. CHEBI:131190
  15. ZINC4074121
  16. BDBM50421878
  17. AKOS030240786
  18. HY-136092
  19. CS-0119570
  20. Q4545687

How does this drug work?[edit | edit source]

It is an EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC and so reduces production of estrogenic steroid hormones.


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