From WikiMD's Food, Medicine & Wellness Encyclopedia


1,4-Butynediol is an organic compound with the formula HOCH2C≡CCH2OH. It is a diol and an alkyne, making it a member of the alkynes and diols chemical families. This compound is a colorless, viscous liquid that is soluble in water and polar organic solvents.

Synthesis[edit | edit source]

1,4-Butynediol is typically synthesized through the Reppe synthesis, which involves the reaction of formaldehyde and acetylene in the presence of a copper-based catalyst. The reaction proceeds as follows:


Applications[edit | edit source]

1,4-Butynediol is used in various industrial applications. It serves as a precursor to other chemicals, including 1,4-Butanediol and tetrahydrofuran. It is also used in the production of certain polymers and pharmaceuticals.

Polymer Industry[edit | edit source]

In the polymer industry, 1,4-Butynediol is used as a monomer for the synthesis of polyurethanes and other polyesters. Its ability to undergo polymerization reactions makes it valuable in creating materials with specific mechanical and chemical properties.

Pharmaceuticals[edit | edit source]

In the pharmaceutical industry, 1,4-Butynediol is used as an intermediate in the synthesis of various drugs. Its reactivity allows for the introduction of functional groups that are essential for the biological activity of these compounds.

Safety and Handling[edit | edit source]

1,4-Butynediol is classified as a hazardous material. It can cause skin and eye irritation upon contact and may be harmful if ingested or inhaled. Proper safety measures, including the use of personal protective equipment (PPE) and adequate ventilation, should be observed when handling this compound.

Related Compounds[edit | edit source]

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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Contributors: Prab R. Tumpati, MD