11-Hydroxy-Δ-8-THC
Chemical compound related to THC
11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ-8-THC) is a cannabinoid that is a metabolite of Δ-8-tetrahydrocannabinol (Δ-8-THC), a naturally occurring compound found in the cannabis plant. It is similar in structure to 11-Hydroxy-Δ-9-THC, the active metabolite of Δ-9-tetrahydrocannabinol (Δ-9-THC), which is the primary psychoactive component of cannabis.
Chemical Structure and Properties[edit | edit source]
11-Hydroxy-Δ-8-THC is a terpenoid compound with the chemical formula C21H30O3. It is structurally similar to other cannabinoids, featuring a tricyclic structure with a hydroxyl group at the 11th carbon position. This hydroxylation is a key factor in its activity as a metabolite.
Pharmacology[edit | edit source]
11-Hydroxy-Δ-8-THC is formed in the body after the consumption of Δ-8-THC. It is produced by the action of the liver enzyme cytochrome P450 on Δ-8-THC, converting it into this more water-soluble form. This metabolite is believed to contribute to the psychoactive effects experienced after the ingestion of Δ-8-THC, similar to how 11-Hydroxy-Δ-9-THC contributes to the effects of Δ-9-THC.
Effects[edit | edit source]
The effects of 11-Hydroxy-Δ-8-THC are not as well-studied as those of 11-Hydroxy-Δ-9-THC, but it is thought to have similar psychoactive properties. It is likely to interact with the endocannabinoid system, particularly the CB1 receptor, which is responsible for the psychoactive effects of cannabinoids.
Metabolism[edit | edit source]
When Δ-8-THC is consumed, it is absorbed into the bloodstream and transported to the liver. There, it undergoes first-pass metabolism, where it is converted into 11-Hydroxy-Δ-8-THC by liver enzymes. This process is similar to the metabolism of Δ-9-THC into 11-Hydroxy-Δ-9-THC.
Legal Status[edit | edit source]
The legal status of 11-Hydroxy-Δ-8-THC is not well-defined, as it is a metabolite of Δ-8-THC. The legality of Δ-8-THC itself varies by jurisdiction, and this indirectly affects the legal status of its metabolites.
Related Compounds[edit | edit source]
See Also[edit | edit source]
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