11-Hydroxyhexahydrocannabinol

11-Hydroxyhexahydrocannabinol

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Chemical structure of 11-Hydroxyhexahydrocannabinol

11-Hydroxyhexahydrocannabinol (11-OH-HHC) is a cannabinoid metabolite that is formed in the body after the consumption of hexahydrocannabinol (HHC). It is analogous to 11-Hydroxy-THC, which is a metabolite of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure

11-Hydroxyhexahydrocannabinol is a hydroxylated form of hexahydrocannabinol. The hydroxyl group is attached to the 11th carbon of the hexahydrocannabinol molecule, which is a common site for metabolic transformation in cannabinoids. This structural modification can influence the compound's pharmacological properties.

Pharmacology

11-Hydroxyhexahydrocannabinol is believed to interact with the endocannabinoid system, similar to other cannabinoids. It may bind to cannabinoid receptors such as CB1 and CB2, although its exact affinity and efficacy at these receptors are not fully characterized. The presence of the hydroxyl group at the 11th position may alter its potency and duration of action compared to its parent compound, HHC.

Metabolism

Metabolic pathway of hydroxylation

The metabolism of hexahydrocannabinol involves hydroxylation at the 11th carbon, leading to the formation of 11-Hydroxyhexahydrocannabinol. This metabolic pathway is similar to that of THC, where 11-Hydroxy-THC is a major active metabolite. The hydroxylation process is typically mediated by cytochrome P450 enzymes in the liver.

Effects

The effects of 11-Hydroxyhexahydrocannabinol are not well-documented, but it is presumed to have psychoactive properties due to its structural similarity to other hydroxylated cannabinoids. The compound may contribute to the overall effects experienced after the consumption of hexahydrocannabinol.

Research

Research on 11-Hydroxyhexahydrocannabinol is limited, and further studies are needed to understand its pharmacokinetics, pharmacodynamics, and potential therapeutic applications. Investigations into its receptor binding profile and metabolic pathways could provide insights into its role in the effects of hexahydrocannabinol.

Related Pages

• Cannabinoid
• Hexahydrocannabinol
• 11-Hydroxy-THC
• Tetrahydrocannabinol