2′-CH3-MPTP

2′-CH3-MPTP is a chemical compound that is structurally related to the neurotoxin MPTP. It is of interest in the field of neuropharmacology and toxicology due to its potential effects on the dopaminergic system and its implications in neurodegenerative diseases.

Chemical Structure and Properties

2′-CH3-MPTP, or 2′-methyl-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, is a derivative of MPTP with a methyl group attached at the 2′ position of the phenyl ring. This modification can influence its pharmacokinetic properties and its interaction with biological systems.

Mechanism of Action

Similar to MPTP, 2′-CH3-MPTP is believed to undergo bioactivation to form a toxic metabolite. MPTP is converted by the enzyme monoamine oxidase B (MAO-B) into MPP+, a potent neurotoxin that selectively targets dopaminergic neurons in the substantia nigra. The exact metabolic pathway and neurotoxic potential of 2′-CH3-MPTP are subjects of ongoing research.

Research and Implications

Research into 2′-CH3-MPTP is primarily focused on understanding its potential as a model compound for studying Parkinson's disease. The compound's ability to induce dopaminergic neurodegeneration in animal models can provide insights into the pathophysiology of Parkinson's disease and aid in the development of therapeutic interventions.

Safety and Toxicology

As with other MPTP analogs, 2′-CH3-MPTP poses significant safety concerns due to its potential neurotoxic effects. Handling and experimentation with this compound require stringent safety protocols to prevent accidental exposure and neurotoxicity.

Also see

• MPTP
• MPP+
• Parkinson's disease
• Dopaminergic system
• Neurotoxicity