2-Iodoxybenzoic acid

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2-Iodoxybenzoic acid (IBX) is an organic compound used primarily in the oxidation of alcohols to aldehydes and ketones. Possessing the chemical formula C₇H₅IO₄, it is a solid at room temperature, appearing as off-white to yellowish crystals. Due to its potent oxidizing capabilities, IBX has found extensive application in synthetic organic chemistry.

Properties and Structure[edit | edit source]

IBX is characterized by its unique structure, where the iodine atom is bonded to an oxygen atom (forming an iodoxy group) and is also part of a benzoic acid moiety. This arrangement is responsible for its oxidative properties. The compound is relatively stable under normal conditions but can decompose explosively upon heating or under impact.

Synthesis[edit | edit source]

The synthesis of IBX involves the reaction of 2-iodobenzoic acid with oxidizing agents such as oxone (potassium peroxymonosulfate). This process typically yields IBX in a moderately high purity, which can then be recrystallized from suitable solvents, such as acetonitrile, to obtain the desired crystal form.

Applications[edit | edit source]

IBX is widely used in organic synthesis, particularly in the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively. Its selectivity and efficiency have made it a valuable tool in the preparation of various organic compounds, including natural products and pharmaceuticals. Additionally, IBX can be employed in the oxidative cleavage of ethers and the dehydrogenation of alcohols.

Safety and Handling[edit | edit source]

Due to its oxidative strength, IBX must be handled with care. It is considered a strong oxidizer and can pose fire and explosion hazards if not managed properly. Appropriate safety measures, including the use of personal protective equipment (PPE) and working in well-ventilated areas, are essential when working with this compound.

Environmental Impact[edit | edit source]

The environmental impact of IBX is an area of ongoing research. As with many chemical reagents, proper disposal methods should be followed to minimize any potential harm to the environment. This includes neutralization of its oxidative properties before disposal.

See Also[edit | edit source]

External Links[edit | edit source]


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Contributors: Prab R. Tumpati, MD