2-Methoxyestradiol disulfamate

2-Methoxyestradiol disulfamate is a synthetic derivative of 2-Methoxyestradiol, a metabolite of estradiol. It is a sulfamate ester and is also known as 2-MeOE2bisMATE. This compound has been studied for its potential use in cancer therapy due to its anti-proliferative and anti-angiogenic properties.

Chemistry

2-Methoxyestradiol disulfamate is a sulfamate ester of 2-Methoxyestradiol. The sulfamate group is added to increase the bioavailability of the compound, as it improves the lipophilicity and stability of the molecule. The addition of the sulfamate group also enhances the anti-proliferative and anti-angiogenic properties of the compound.

Pharmacology

The pharmacological action of 2-Methoxyestradiol disulfamate is primarily due to its anti-proliferative and anti-angiogenic properties. It inhibits the proliferation of cancer cells and the formation of new blood vessels, which are crucial for the growth and spread of cancer. The compound achieves this by inhibiting the tubulin polymerization and disrupting the microtubule network, which is essential for cell division and angiogenesis.

Clinical Use

2-Methoxyestradiol disulfamate is currently under investigation for its potential use in cancer therapy. Preliminary studies have shown promising results in inhibiting the growth and spread of various types of cancer, including breast cancer, prostate cancer, and ovarian cancer. However, further research is needed to confirm these findings and to determine the safety and efficacy of this compound in humans.

See Also

• 2-Methoxyestradiol
• Sulfamate
• Cancer therapy
• Anti-angiogenic therapy

References

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