2-Methoxyestradiol disulfamate

2-Methoxyestradiol disulfamate is a synthetic estrogen derivative that has been studied for its potential use in cancer therapy. It is a sulfamoylated analog of 2-Methoxyestradiol, a naturally occurring metabolite of estradiol.

Chemical Properties

2-Methoxyestradiol disulfamate is characterized by the addition of sulfamate groups to the 2-methoxyestradiol molecule. This modification enhances its bioavailability and pharmacokinetics, making it a more potent agent in inhibiting tumor growth.

Mechanism of Action

The compound acts by disrupting the microtubule network within cancer cells, leading to cell cycle arrest and apoptosis. It also inhibits angiogenesis, the process by which new blood vessels form from pre-existing vessels, which is crucial for tumor growth and metastasis.

Therapeutic Potential

2-Methoxyestradiol disulfamate has shown promise in preclinical studies as an anti-cancer agent. It is particularly effective against breast cancer, prostate cancer, and ovarian cancer. Its ability to target multiple pathways involved in cancer progression makes it a candidate for further clinical development.

Related Compounds

• 2-Methoxyestradiol
• Estradiol
• Sulfamate

Related Pages

• Cancer therapy
• Estrogen receptor
• Microtubule inhibitors