2-Methyl-6-(phenylethynyl)pyridine

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Chemical compound



2-Methyl-6-(phenylethynyl)pyridine (MPEP) is a chemical compound that acts as a selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). It is used primarily in scientific research to study the role of mGluR5 in various physiological and pathological processes.

Chemical structure and properties[edit | edit source]

2-Methyl-6-(phenylethynyl)pyridine is a derivative of pyridine, a basic heterocyclic organic compound. The structure of MPEP includes a pyridine ring substituted with a methyl group at the 2-position and a phenylethynyl group at the 6-position. This specific substitution pattern is crucial for its activity as an mGluR5 antagonist.

Mechanism of action[edit | edit source]

MPEP functions by selectively binding to the mGluR5 receptor, inhibiting its activity. The mGluR5 receptor is a member of the group I metabotropic glutamate receptors, which are G-protein coupled receptors involved in modulating synaptic transmission and plasticity in the central nervous system. By blocking mGluR5, MPEP can modulate glutamatergic signaling, which is implicated in various neurological and psychiatric disorders.

Applications in research[edit | edit source]

MPEP is widely used in neuroscience research to investigate the role of mGluR5 in conditions such as anxiety, depression, schizophrenia, and Parkinson's disease. It has also been studied for its potential therapeutic effects in fragile X syndrome, a genetic disorder characterized by intellectual disability and behavioral challenges.

Pharmacological effects[edit | edit source]

In preclinical studies, MPEP has been shown to produce anxiolytic and antidepressant-like effects in animal models. It also exhibits neuroprotective properties, making it a valuable tool for exploring the therapeutic potential of mGluR5 antagonism in neurodegenerative diseases.

Safety and toxicity[edit | edit source]

As with many research chemicals, the safety and toxicity profile of MPEP in humans is not well-established. It is primarily used in laboratory settings under controlled conditions to minimize potential risks.

Related pages[edit | edit source]

Gallery[edit | edit source]

  • Chemical structure of 2-Methyl-6-(phenylethynyl)pyridine

  • 2-Methyl-6-(phenylethynyl)pyridine

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Contributors: Prab R. Tumpati, MD