2-Methyl-6-(phenylethynyl)pyridine

2-Methyl-6-(phenylethynyl)pyridine (also known as MPEP) is a chemical compound and research chemical that is used in scientific studies. It acts as a non-competitive antagonist at the mGluR5 receptor and is used in research to explore the role of this receptor in the central nervous system.

Chemistry[edit | edit source]

2-Methyl-6-(phenylethynyl)pyridine is a pyridine derivative. The compound contains a methyl group at the 2-position and a phenylethynyl group at the 6-position of the pyridine ring. The phenylethynyl group is a phenyl group attached to an ethynyl group, which consists of two carbon atoms triple-bonded together and a single hydrogen atom.

Pharmacology[edit | edit source]

MPEP acts as a non-competitive antagonist at the mGluR5 receptor, a type of metabotropic glutamate receptor. These receptors are found in various regions of the brain and are involved in a variety of neurological processes. By blocking the activity of mGluR5, MPEP can be used to study the role of this receptor in the central nervous system.

Uses in Research[edit | edit source]

MPEP has been used in a variety of research studies. For example, it has been used to investigate the role of mGluR5 in pain perception, anxiety, and drug addiction. It has also been used to study the potential therapeutic effects of mGluR5 antagonists in conditions such as schizophrenia and Parkinson's disease.

Safety[edit | edit source]

As a research chemical, MPEP is not intended for human consumption. Its safety profile in humans is not well-studied, and it should be handled with care in a research setting.