From WikiMD's Food, Medicine & Wellness Encyclopedia

2-Propanoyl-3-(4-isopropylphenyl)-tropane (also known as PIT) is a cocaine analogue. It is a potent monoamine reuptake inhibitor with stimulant effects. This compound is used in scientific research for its properties and its interactions with the central nervous system.

Chemistry[edit | edit source]

2-Propanoyl-3-(4-isopropylphenyl)-tropane is a tropane derivative. Tropanes are a class of bicyclic alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. The compound is structurally similar to cocaine, which is also a tropane derivative. However, the 2-propanoyl-3-(4-isopropylphenyl) substitution on the tropane ring differentiates it from cocaine.

Pharmacology[edit | edit source]

As a monoamine reuptake inhibitor, 2-Propanoyl-3-(4-isopropylphenyl)-tropane blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin in the brain. This leads to an increase in the extracellular concentrations of these neurotransmitters and an increase in neurotransmission. The compound is believed to exert its stimulant effects through this mechanism of action.

Research Use[edit | edit source]

2-Propanoyl-3-(4-isopropylphenyl)-tropane is used in scientific research to study the effects of monoamine reuptake inhibitors and to develop new treatments for conditions such as depression, anxiety disorders, and attention deficit hyperactivity disorder (ADHD). The compound's structural similarity to cocaine also makes it a useful tool in research into addiction and substance abuse.

Safety and Legal Status[edit | edit source]

As a potent stimulant and monoamine reuptake inhibitor, 2-Propanoyl-3-(4-isopropylphenyl)-tropane has the potential for abuse and addiction. Its use is therefore regulated under various drug control laws. In many jurisdictions, it is classified as a controlled substance.


Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD