20-Hydroxyeicosatetraenoic acid
A metabolite of arachidonic acid
20-Hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid, an important polyunsaturated fatty acid in the human body. It is produced by the action of cytochrome P450 enzymes, specifically the CYP4A and CYP4F subfamilies. 20-HETE plays a significant role in the regulation of vascular tone, renal function, and blood pressure.
Biosynthesis[edit | edit source]
20-HETE is synthesized from arachidonic acid through the action of cytochrome P450 enzymes. These enzymes hydroxylate arachidonic acid at the omega-terminus, specifically at the 20th carbon, to produce 20-HETE. The CYP4A and CYP4F subfamilies are primarily responsible for this conversion.
Physiological roles[edit | edit source]
20-HETE is involved in various physiological processes:
- Vascular tone regulation: 20-HETE acts as a potent vasoconstrictor in the cerebral, renal, and coronary circulations. It modulates the activity of ion channels and smooth muscle contraction, influencing blood flow and pressure.
- Renal function: In the kidneys, 20-HETE regulates sodium and water excretion, affecting glomerular filtration rate and tubular reabsorption. It plays a role in renal autoregulation and blood pressure control.
- Inflammation and cell proliferation: 20-HETE has been implicated in inflammatory responses and cell proliferation, influencing processes such as angiogenesis and tumor growth.
Pathophysiological implications[edit | edit source]
Abnormal levels of 20-HETE have been associated with various diseases and conditions:
- Hypertension: Elevated 20-HETE levels have been linked to the development of hypertension, particularly in salt-sensitive individuals.
- Stroke and cardiovascular diseases: Due to its role in vascular tone regulation, 20-HETE is implicated in the pathogenesis of stroke and other cardiovascular diseases.
- Cancer: 20-HETE has been shown to promote tumor growth and metastasis in certain types of cancer, making it a potential target for therapeutic intervention.
Research and therapeutic potential[edit | edit source]
Research into 20-HETE is ongoing, with studies exploring its potential as a therapeutic target. Inhibitors of 20-HETE synthesis or action are being investigated for their potential to treat hypertension, stroke, and cancer.
Related pages[edit | edit source]
Gallery[edit | edit source]
Chemical structure of 20-HETE
20-Hydroxyeicosatetraenoic acid[edit | edit source]
Chemical structure of 20-Hydroxyeicosatetraenoic acid
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
