3-Deoxy-D-manno-oct-2-ulosonic acid
3-Deoxy-D-manno-oct-2-ulosonic acid 3-Deoxy-D-manno-oct-2-ulosonic acid, also known as KDO, is a sugar derivative that plays a crucial role in the biosynthesis of lipopolysaccharides in Gram-negative bacteria. It is a key component of the outer membrane of these bacteria and is essential for their survival.
Structure and Properties[edit | edit source]
3-Deoxy-D-manno-oct-2-ulosonic acid is a monosaccharide with a unique eight-carbon backbone. It is classified as a keto sugar due to the presence of a ketone group in its structure. The chemical formula of KDO is C8H14O7.
Biosynthesis[edit | edit source]
The biosynthesis of 3-Deoxy-D-manno-oct-2-ulosonic acid involves several enzymatic steps that convert precursor molecules into the final product. These steps are tightly regulated to ensure the proper formation of KDO in bacterial cells.
Function[edit | edit source]
KDO is primarily found in the lipopolysaccharides of Gram-negative bacteria, where it contributes to the structural integrity of the outer membrane. It also plays a role in host-pathogen interactions and is recognized by the immune system as a pathogen-associated molecular pattern.
Role in Pathogenesis[edit | edit source]
The presence of 3-Deoxy-D-manno-oct-2-ulosonic acid in the outer membrane of Gram-negative bacteria is essential for their virulence. Mutants lacking KDO are often attenuated in their ability to cause disease, highlighting the importance of this sugar derivative in bacterial pathogenesis.
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD