3-Fluorophenmetrazine

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3-Fluorophenmetrazine (3-FPM) is a stimulant of the phenylmorpholine class that produces classical stimulant effects when administered. It is a derivative of phenmetrazine, a once-popular stimulant substance that was clinically used as an anorectic in Europe in the 1950s and 1960s.

History[edit | edit source]

3-Fluorophenmetrazine was first synthesized in the 1970s as part of a series of phenmetrazine analogs, but its activity was not reported until 2014. It was initially developed as a potential medication for obesity, but was never marketed.

Pharmacology[edit | edit source]

3-Fluorophenmetrazine acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), increasing levels of these neurotransmitters in the brain. This leads to increased alertness, focus, and euphoria. The exact mechanism of action is not fully understood, but it is believed to involve the inhibition of monoamine reuptake.

Effects[edit | edit source]

The effects of 3-Fluorophenmetrazine can vary greatly depending on the dose, individual physiology, and method of administration. Common effects include stimulation, increased focus, euphoria, and increased sociability. At higher doses, it can cause anxiety, paranoia, and hallucinations.

Legal Status[edit | edit source]

The legal status of 3-Fluorophenmetrazine varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use. It is important to check local laws before purchasing or using this substance.

Health Risks[edit | edit source]

As with all stimulants, 3-Fluorophenmetrazine carries a risk of addiction and physical dependence. It can also cause a range of negative health effects, including increased heart rate, high blood pressure, and potential damage to the cardiovascular system. Long-term use can lead to mental health issues such as depression and anxiety.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD