3-Methylhistidine
(Redirected from 3-methylhistidine)
3-Methylhistidine is an amino acid that is a derivative of the essential amino acid histidine. It is not incorporated into proteins but is free in the muscle tissue and is excreted in the urine. 3-Methylhistidine is a marker of muscle protein breakdown.
Structure and Properties[edit | edit source]
3-Methylhistidine has a molecular weight of 169.18 g/mol. It is a white crystalline powder that is soluble in water. The chemical formula for 3-Methylhistidine is C7H11N3O2.
Biological Role[edit | edit source]
3-Methylhistidine is formed by the methylation of the imidazole ring of histidine residues in certain proteins, particularly in the contractile proteins actin and myosin. This methylation is irreversible in humans, so the release of 3-Methylhistidine is an indicator of muscle protein breakdown.
Clinical Significance[edit | edit source]
Measurement of urinary 3-Methylhistidine has been used as a diagnostic tool to assess muscle protein breakdown in various conditions such as cachexia, muscular dystrophy, and cancer. It can also be used to monitor the effectiveness of treatment in these conditions.
See Also[edit | edit source]
- Amino Acid
- Histidine
- Muscle Tissue
- Urine
- Molecular Weight
- Chemical Formula
- Methylation
- Actin
- Myosin
- Cachexia
- Muscular Dystrophy
- Cancer
3-Methylhistidine Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD