4-1BB ligand

4-1BB ligand (also known as 4-1BBL or CD137L) is a protein that in humans is encoded by the TNFSF9 gene. It is a member of the tumor necrosis factor (TNF) superfamily, a group of proteins that play a crucial role in inflammatory, immune, and apoptotic processes.

Function

4-1BB ligand is a type of cell surface molecule that provides a costimulatory signal necessary for T cell activation and survival. It interacts with its receptor, 4-1BB, to regulate immune responses, particularly the activity of T cells. This interaction is important for the proliferation and survival of T cells, as well as their production of cytokines.

Clinical significance

Due to its role in T cell activation, 4-1BB ligand has been implicated in various immune system disorders, including autoimmune diseases and cancer. In cancer, the 4-1BB/4-1BBL interaction can be exploited to enhance anti-tumor immunity. This has led to the development of immunotherapy strategies that target 4-1BB or 4-1BBL, with the aim of boosting the immune system's ability to fight cancer.

See also

• 4-1BB
• Tumor necrosis factor (TNF)
• T cell
• Immunotherapy