40S ribosomal protein S13

Ideogram human chromosome 11

40S ribosomal protein S13

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene. This protein is a component of the 40S subunit of the ribosome, which is essential for protein synthesis in all living organisms. The RPS13 gene is located on chromosome 2 in humans.

Structure

The 40S ribosomal protein S13 is a small protein consisting of approximately 100 amino acids. It plays a crucial role in the assembly and function of the ribosome by interacting with other ribosomal proteins and ribosomal RNA.

Function

As a component of the 40S subunit, ribosomal protein S13 is involved in the decoding of messenger RNA (mRNA) during translation. It helps to position the mRNA on the ribosome and ensures accurate base pairing between the mRNA codon and the transfer RNA (tRNA) anticodon.

Clinical Significance

Mutations in the RPS13 gene have been associated with various human diseases, including cancer and genetic disorders. Dysregulation of ribosomal proteins like S13 can lead to abnormal protein synthesis and cellular dysfunction.

Interactions

Ribosomal protein S13 interacts with other ribosomal proteins, ribosomal RNA, and translation factors to facilitate the ribosome's function in protein synthesis. These interactions are essential for the proper assembly and activity of the ribosome.