40S ribosomal protein S27a

Protein RPS27A PDB 1aar

40S Ribosomal Protein S27a

40S Ribosomal Protein S27a is a protein that in humans is encoded by the RPS27A gene. It is a component of the 40S subunit of the ribosome, which is essential for protein synthesis in all living organisms. This protein plays a crucial role in the translation process by aiding in the assembly of the ribosome and facilitating the binding of mRNA and tRNAs.

Structure

40S Ribosomal Protein S27a is a small protein consisting of 82 amino acids. It is highly conserved across different species, indicating its importance in the ribosomal function. The protein interacts with other ribosomal proteins and ribosomal RNA to form the functional 40S subunit.

Function

As a component of the 40S subunit, 40S Ribosomal Protein S27a participates in the decoding of mRNA during translation. It helps in the accurate positioning of the mRNA on the ribosome and ensures the proper alignment of the tRNAs carrying amino acids. This protein also plays a role in the quality control mechanisms of the ribosome to prevent errors in protein synthesis.

Clinical Significance

Mutations in the RPS27A gene or dysregulation of 40S Ribosomal Protein S27a expression have been associated with various diseases, including cancer and neurodegenerative disorders. Studies have shown that alterations in ribosomal proteins can lead to abnormal protein synthesis and contribute to the development of these conditions.