6,14-Endoethenotetrahydrooripavine

6,14-Endoethenotetrahydrooripavine is a semi-synthetic opioid compound derived from thebaine. It is a potent analgesic, approximately 18 times more potent than morphine. The compound is not currently used in medicine and is not commercially available.

Chemistry

6,14-Endoethenotetrahydrooripavine is a derivative of thebaine, a naturally occurring opiate alkaloid. The compound is structurally similar to other thebaine derivatives such as oxycodone and buprenorphine. The synthesis of 6,14-endoethenotetrahydrooripavine involves the reaction of thebaine with acetic anhydride, followed by reduction with lithium aluminum hydride.

Pharmacology

As an opioid, 6,14-endoethenotetrahydrooripavine acts on the mu-opioid receptor, producing analgesic effects. The compound is a potent agonist at this receptor, with a binding affinity approximately 18 times greater than that of morphine. The exact mechanism of action is not fully understood, but it is believed to involve inhibition of pain signals in the central nervous system.

Potential Medical Uses

While 6,14-endoethenotetrahydrooripavine is not currently used in medicine, its potent analgesic effects suggest potential applications in the treatment of severe pain. However, like other opioids, it also carries a high risk of addiction and other adverse effects, which may limit its clinical utility.

See Also

• Opioid
• Thebaine
• Morphine
• Oxycodone
• Buprenorphine

References

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