60S ribosomal protein L3

Ideogram human chromosome 22

60S Ribosomal Protein L3

60S Ribosomal Protein L3 is a vital component of the ribosome, a complex molecular machine responsible for protein synthesis in cells. This protein is found in the large subunit of the ribosome and plays a crucial role in the translation process by aiding in the formation of peptide bonds between amino acids.

Structure

60S Ribosomal Protein L3 is a conserved protein that is essential for the proper functioning of the ribosome. It consists of a specific arrangement of amino acids that allows it to interact with other ribosomal proteins and RNA molecules within the ribosome. The structure of this protein is highly dynamic, allowing it to undergo conformational changes during the translation process.

Function

As a component of the ribosome, 60S Ribosomal Protein L3 plays a key role in the elongation phase of protein synthesis. It interacts with the ribosomal RNA and other ribosomal proteins to facilitate the binding of transfer RNA molecules and the formation of peptide bonds between amino acids. This protein is essential for the accurate and efficient translation of messenger RNA into protein.

Role in Disease

Mutations in the gene encoding 60S Ribosomal Protein L3 have been associated with various diseases, including Diamond-Blackfan anemia and cancer. Disruption of the normal function of this protein can lead to defects in ribosome biogenesis and protein synthesis, resulting in cellular dysfunction and disease.