60S ribosomal protein L35

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene. This protein is a component of the 60S ribosomal subunit, which is part of the ribosome, the cell's molecular machine for protein synthesis. Ribosomal proteins play a key role in the function of the ribosome, facilitating the assembly of the ribosomal subunits and ensuring the proper translation of mRNA into protein.

Function

The 60S ribosomal protein L35 is integral to the structure and function of the ribosome's large subunit. It participates in the assembly of the ribosome and is involved in the process of translation, where genetic information encoded in mRNA is decoded to synthesize proteins. This protein, like other ribosomal proteins, contributes to the stability and fidelity of the ribosome during this process.

Gene

The RPL35 gene is located on chromosome 3 in humans. It encodes the 60S ribosomal protein L35, which is one of the many proteins that constitute the large subunit of the ribosome. The regulation of this gene, along with others encoding ribosomal proteins, is crucial for the control of protein synthesis and cellular growth.

Clinical Significance

Alterations in the expression or function of ribosomal proteins, including 60S ribosomal protein L35, can have significant impacts on cellular function and can contribute to diseases. For example, mutations in ribosomal protein genes have been associated with ribosomopathies, a group of disorders characterized by defects in ribosome function. However, specific diseases directly linked to mutations in the RPL35 gene have not been extensively documented.

Evolution

Ribosomal proteins are highly conserved throughout evolution, highlighting their fundamental role in the biology of all cellular life. The 60S ribosomal protein L35 shares a high degree of similarity across different species, from yeast to humans, indicating its essential function in the ribosome's structure and the process of protein synthesis.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins
• Translation (biology)