60S ribosomal protein L7a

Ideogram human chromosome 9

== 60S Ribosomal Protein L7a ==

60S Ribosomal Protein L7a is a protein that in humans is encoded by the RPL7A gene. It is a component of the 60S subunit of the ribosome, which is essential for protein synthesis in cells.

Structure

60S Ribosomal Protein L7a is a ribosomal protein that plays a crucial role in the assembly and function of the ribosome. It is composed of a single polypeptide chain and interacts with other ribosomal proteins to form the large subunit of the ribosome.

Function

As a component of the 60S subunit, 60S Ribosomal Protein L7a is involved in the translation of messenger RNA (mRNA) into proteins. It helps to stabilize the binding of tRNA molecules to the ribosome and facilitates the formation of peptide bonds between amino acids during protein synthesis.

Clinical Significance

Mutations in the RPL7A gene encoding 60S Ribosomal Protein L7a have been associated with various diseases, including cancer and developmental disorders. Dysregulation of ribosomal proteins like L7a can lead to abnormal protein synthesis and cellular dysfunction.

References

1. RPL7A gene information 2. Role of ribosomal protein L7a in translation