7-Me-Marsanidine

7-Me-Marsanidine is a chemical compound that acts as a selective agonist for the imidazoline receptors, particularly the I₁ subtype. It is structurally related to marsanidine, with the addition of a methyl group at the 7-position of the imidazoline ring, which enhances its selectivity and potency.

Chemical Structure and Properties

7-Me-Marsanidine is a derivative of the imidazoline class of compounds. Its chemical structure is characterized by the presence of an imidazoline ring, which is a five-membered ring containing two nitrogen atoms. The addition of a methyl group at the 7-position distinguishes it from its parent compound, marsanidine.

• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23 g/mol
• Chemical Structure:

 ![7-Me-Marsanidine structure](https://example.com/7-Me-Marsanidine_structure.png)

Pharmacological Action

7-Me-Marsanidine is primarily known for its action on the imidazoline receptors. These receptors are involved in various physiological processes, including the regulation of blood pressure and insulin secretion. The I₁ subtype, in particular, is implicated in the modulation of sympathetic nervous system activity.

Mechanism of Action

7-Me-Marsanidine binds selectively to the I₁ imidazoline receptors, which are located in the central nervous system and peripheral tissues. Upon binding, it activates these receptors, leading to a decrease in sympathetic outflow and a subsequent reduction in blood pressure. This makes it a potential candidate for the treatment of hypertension.

Research and Development

Research on 7-Me-Marsanidine is ongoing, with studies focusing on its potential therapeutic applications and its role in elucidating the function of imidazoline receptors. Its high selectivity for the I₁ receptor makes it a valuable tool in pharmacological research.

Potential Applications

Due to its ability to modulate blood pressure, 7-Me-Marsanidine is being investigated as a potential antihypertensive agent. Additionally, its effects on insulin secretion suggest possible applications in the management of diabetes mellitus.

Safety and Toxicology

As with any pharmacological agent, the safety profile of 7-Me-Marsanidine is a critical area of study. Preliminary studies indicate that it is well-tolerated at therapeutic doses, but further research is needed to fully understand its long-term effects and potential toxicity.

Also see

• Imidazoline receptor
• Marsanidine
• Antihypertensive drugs
• Sympathetic nervous system