9α-Bromo-11-ketoprogesterone

9α-Bromo-11-ketoprogesterone is a synthetic steroid that is related to progesterone, a naturally occurring steroid hormone. It is a potent glucocorticoid and has been used in scientific research to study the effects of glucocorticoids on the body.

Chemistry

9α-Bromo-11-ketoprogesterone is a derivative of progesterone, which is a naturally occurring steroid hormone. It is synthesized by bromination of progesterone at the 9α position and oxidation of the 11 position to a ketone. The bromination increases the potency of the steroid, while the ketone group at the 11 position confers glucocorticoid activity.

Pharmacology

As a glucocorticoid, 9α-Bromo-11-ketoprogesterone has potent anti-inflammatory and immunosuppressive effects. It works by binding to the glucocorticoid receptor, a type of nuclear receptor that regulates gene expression. When 9α-Bromo-11-ketoprogesterone binds to the glucocorticoid receptor, it alters the transcription of certain genes, leading to changes in the immune response and inflammation.

Research Use

9α-Bromo-11-ketoprogesterone has been used in scientific research to study the effects of glucocorticoids on the body. It has been used in studies investigating the role of glucocorticoids in inflammation, immune response, and various diseases.

See Also

• Glucocorticoid
• Progesterone
• Steroid hormone
• Nuclear receptor

References

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