9-Hydroxyoctadecadienoic acid
9-Hydroxyoctadecadienoic acid[edit | edit source]
9-Hydroxyoctadecadienoic acid, commonly abbreviated as 9-HODE, is a type of hydroxy fatty acid derived from the oxidation of linoleic acid. It is one of the primary products formed during the lipid peroxidation process and is often used as a biomarker for oxidative stress in biological systems.
Chemical Structure[edit | edit source]
9-HODE is a monohydroxy fatty acid with the chemical formula C__H__O_. It is characterized by the presence of a hydroxyl group at the ninth carbon of the octadecadienoic acid chain. The molecule contains two cis double bonds located at the 9th and 12th carbon positions, which are typical of linoleic acid derivatives.
Biological Role[edit | edit source]
9-HODE plays a significant role in various biological processes. It is involved in the regulation of inflammation and has been shown to modulate the activity of peroxisome proliferator-activated receptors (PPARs), which are nuclear receptors that regulate the expression of genes involved in lipid metabolism, glucose homeostasis, and cell proliferation.
Formation and Metabolism[edit | edit source]
9-HODE is formed through the enzymatic and non-enzymatic oxidation of linoleic acid. The enzymatic pathway involves the action of lipoxygenases, while the non-enzymatic pathway involves free radical-mediated oxidation. Once formed, 9-HODE can be further metabolized by various enzymes, including cytochrome P450s and alcohol dehydrogenases, to produce other bioactive lipid mediators.
Clinical Significance[edit | edit source]
Elevated levels of 9-HODE have been associated with several pathological conditions, including atherosclerosis, diabetes mellitus, and cancer. It is often used as a biomarker to assess oxidative stress and lipid peroxidation in clinical studies. The presence of 9-HODE in tissues and biological fluids can provide insights into the oxidative status of an organism and the potential risk for developing oxidative stress-related diseases.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
