AA-861

AA-861 is a chemical compound that functions as a selective leukotriene synthesis inhibitor. It is primarily used in research settings to study the role of leukotrienes in various inflammatory processes.

Mechanism of Action

AA-861 inhibits the enzyme 5-lipoxygenase (5-LO), which is crucial in the biosynthesis of leukotrienes from arachidonic acid. Leukotrienes are lipid compounds that play a significant role in the pathophysiology of inflammatory diseases, such as asthma, allergic rhinitis, and rheumatoid arthritis. By inhibiting 5-LO, AA-861 reduces the production of leukotrienes, thereby potentially mitigating inflammatory responses.

Pharmacological Effects

In preclinical studies, AA-861 has demonstrated efficacy in reducing leukotriene-mediated inflammation. It has been shown to decrease bronchoconstriction and airway hyperresponsiveness in animal models of asthma. Additionally, AA-861 has been used to explore the role of leukotrienes in other inflammatory conditions, providing insights into potential therapeutic targets.

Research Applications

AA-861 is primarily used in laboratory research to:

• Investigate the role of leukotrienes in inflammatory diseases.
• Evaluate the potential therapeutic effects of leukotriene inhibition.
• Study the biochemical pathways involved in leukotriene synthesis.

Safety and Toxicology

As a research chemical, AA-861 is not approved for human use. Its safety profile in humans is not well-established, and it should be handled with caution in laboratory settings. Researchers should follow appropriate safety protocols when working with AA-861.

Also see

• Leukotriene receptor antagonist
• 5-lipoxygenase inhibitor
• Arachidonic acid
• Inflammation