ACTR2

Protein ACTR2 PDB 1k8k

ACTR2

ACTR2 is a gene that encodes a protein known as Actin-related protein 2. This protein is a component of the Arp2/3 complex, which plays a crucial role in the regulation of the actin cytoskeleton. The Arp2/3 complex is involved in the nucleation of new actin filaments, which are essential for various cellular processes such as cell motility, cell division, and intracellular transport.

Function

The primary function of the ACTR2 gene is to encode the Actin-related protein 2, which, along with other subunits of the Arp2/3 complex, promotes the formation of branched actin filaments. These branched filaments are necessary for the dynamic remodeling of the actin cytoskeleton, which is essential for cell shape changes, cell migration, and other cellular activities.

Clinical Significance

Mutations in the ACTR2 gene have been associated with certain genetic disorders and diseases. For example, mutations in ACTR2 have been linked to developmental abnormalities and intellectual disabilities. Additionally, dysregulation of the Arp2/3 complex, due to mutations in ACTR2 or other subunits, can lead to defects in cell motility and contribute to the progression of certain cancers.

Interactions

The ACTR2 protein interacts with various other proteins within the Arp2/3 complex and with regulators of actin dynamics. These interactions are crucial for the proper functioning of the Arp2/3 complex and the regulation of actin polymerization in cells.