AF64A

AF64A is a neurotoxin that is used in scientific research to induce cholinergic neuron damage and create models of Alzheimer's disease. It is a derivative of ethylenediamine, and its full chemical name is ethylcholine mustard aziridinium ion.

Mechanism of Action

AF64A acts by entering cholinergic neurons via the choline transporter. Once inside the neuron, it forms a reactive aziridinium ion that alkylates intracellular components, leading to cell death. The damage caused by AF64A is selective for cholinergic neurons, making it a useful tool for studying the role of these neurons in cognition and memory.

Use in Research

In research, AF64A is used to create animal models of Alzheimer's disease. By damaging cholinergic neurons, it induces cognitive deficits similar to those seen in Alzheimer's disease. This allows researchers to study the disease's progression and potential treatments in a controlled laboratory setting.

Safety

As a neurotoxin, AF64A must be handled with care. It can cause harm if it is swallowed, inhaled, or comes into contact with the skin. Appropriate safety measures, including the use of personal protective equipment, should be taken when working with this substance.

See Also

• Neurotoxin
• Alzheimer's disease
• Cholinergic neuron
• Ethylenediamine

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