ALZ-801
ALZ-801 is an investigational drug being developed for the treatment of Alzheimer's disease. It is a prodrug of tramiprosate, designed to inhibit the formation of amyloid plaques in the brain, which are characteristic of Alzheimer's disease.
Mechanism of Action[edit | edit source]
ALZ-801 works by inhibiting the aggregation of amyloid-beta peptides into toxic oligomers and fibrils. These amyloid-beta aggregates are believed to play a critical role in the pathogenesis of Alzheimer's disease by disrupting cell function and triggering neuroinflammation.
Clinical Development[edit | edit source]
ALZ-801 is currently undergoing clinical trials to evaluate its safety and efficacy in patients with Alzheimer's disease. The drug has shown promise in early-phase trials, demonstrating a reduction in amyloid-beta levels and cognitive decline in patients.
Pharmacokinetics[edit | edit source]
As a prodrug, ALZ-801 is metabolized into its active form, tramiprosate, in the body. This allows for improved bioavailability and a more favorable pharmacokinetic profile compared to tramiprosate alone.
Potential Benefits[edit | edit source]
The development of ALZ-801 is significant because it offers a novel approach to treating Alzheimer's disease by targeting the underlying pathology rather than just alleviating symptoms. If successful, it could provide a new therapeutic option for patients with this debilitating condition.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
