ALZ-801
ALZ-801 is an investigational drug being developed for the treatment of Alzheimer's disease. It is a prodrug of tramiprosate, designed to inhibit the formation of amyloid plaques in the brain, which are characteristic of Alzheimer's disease.
Mechanism of Action[edit | edit source]
ALZ-801 works by inhibiting the aggregation of amyloid-beta peptides into toxic oligomers and fibrils. These amyloid-beta aggregates are believed to play a critical role in the pathogenesis of Alzheimer's disease by disrupting cell function and triggering neuroinflammation.
Clinical Development[edit | edit source]
ALZ-801 is currently undergoing clinical trials to evaluate its safety and efficacy in patients with Alzheimer's disease. The drug has shown promise in early-phase trials, demonstrating a reduction in amyloid-beta levels and cognitive decline in patients.
Pharmacokinetics[edit | edit source]
As a prodrug, ALZ-801 is metabolized into its active form, tramiprosate, in the body. This allows for improved bioavailability and a more favorable pharmacokinetic profile compared to tramiprosate alone.
Potential Benefits[edit | edit source]
The development of ALZ-801 is significant because it offers a novel approach to treating Alzheimer's disease by targeting the underlying pathology rather than just alleviating symptoms. If successful, it could provide a new therapeutic option for patients with this debilitating condition.
Related Pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
