AM-404

AM-404 (also known as N-arachidonoylphenolamine) is a direct-acting cannabinoid receptor agonist. It is an active metabolite of the analgesic paracetamol (acetaminophen), responsible for its effects in the body. AM-404 inhibits the reuptake of the endocannabinoid anandamide by cells, making it a key compound in the endocannabinoid system.

Pharmacology

AM-404 is a potent agonist for the cannabinoid receptors CB1 and CB2. It is also a weak vanilloid receptor 1 (TRPV1) agonist, which is believed to be involved in the analgesic effects of paracetamol. AM-404 is thought to be the primary active metabolite responsible for the analgesic effects of paracetamol.

Metabolism

AM-404 is formed from paracetamol in the body by the action of fatty acid amide hydrolase (FAAH). This enzyme breaks down anandamide and other endocannabinoids in the body, and is also responsible for the conversion of paracetamol to AM-404.

Clinical significance

The discovery of AM-404 and its role in the body has led to a new understanding of the analgesic effects of paracetamol. It has also led to the development of new drugs that target the endocannabinoid system, such as the FAAH inhibitors.

See also

• Cannabinoid receptor
• Endocannabinoid system
• Fatty acid amide hydrolase
• Paracetamol

AM-404 Resources
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