AR-C 102222

AR-C 102222

AR-C 102222 is a chemical compound that has been studied for its potential pharmacological effects. It is primarily known as a selective antagonist of the P2Y1 receptor, which is a subtype of the purinergic receptor family. These receptors are activated by nucleotides such as ATP and ADP, and they play significant roles in various physiological processes, including platelet aggregation, muscle contraction, and neurotransmission.

Chemical Structure and Properties

AR-C 102222 is a small molecule with a complex chemical structure. The molecular formula is C₁₉H₂₀N₆O₃, and it has a molecular weight of 380.4 g/mol. The compound is characterized by its ability to bind selectively to the P2Y1 receptor, thereby inhibiting its activity.

Mechanism of Action

The primary mechanism of action of AR-C 102222 involves its antagonistic effects on the P2Y1 receptor. By binding to this receptor, AR-C 102222 prevents the natural ligand, ADP, from activating the receptor. This inhibition can lead to a decrease in platelet aggregation, making AR-C 102222 a compound of interest in the study of antithrombotic therapies.

Pharmacological Effects

AR-C 102222 has been shown to have several pharmacological effects due to its action on the P2Y1 receptor:

• Antithrombotic Effects: By inhibiting platelet aggregation, AR-C 102222 may reduce the risk of thrombus formation, which is a critical factor in conditions such as myocardial infarction and stroke.
• Vasodilation: The compound may also influence vascular tone by affecting smooth muscle contraction, potentially leading to vasodilation.
• Neuroprotective Effects: There is ongoing research into the potential neuroprotective effects of P2Y1 receptor antagonists, including AR-C 102222, in conditions such as ischemic stroke.

Research and Development

Research on AR-C 102222 is primarily focused on its potential therapeutic applications in cardiovascular diseases and neurological disorders. Preclinical studies have demonstrated its efficacy in animal models, but further research is needed to evaluate its safety and effectiveness in humans.

Potential Clinical Applications

The potential clinical applications of AR-C 102222 include:

• Treatment of Thrombotic Disorders: Due to its antiplatelet effects, AR-C 102222 could be developed as a treatment for preventing thrombosis in patients at risk of heart attacks or strokes.
• Neurological Disorders: Its role in modulating neurotransmission and neuroprotection suggests potential use in treating neurological conditions such as stroke or epilepsy.

Also see

• P2Y Receptor
• Platelet Aggregation
• Antithrombotic Therapy
• Neuroprotection