ARPC1B

Protein ARPC1B PDB 1k8k

ARPC1B

ARPC1B, also known as Actin Related Protein 2/3 Complex Subunit 1B, is a protein that in humans is encoded by the ARPC1B gene. This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 complex is involved in the regulation of actin polymerization in cells.

Structure

ARPC1B is a subunit of the Arp2/3 complex, which consists of seven subunits in total. The complex is composed of two actin-related proteins, Arp2 and Arp3, as well as five other subunits, including ARPC1B. ARPC1B plays a crucial role in the nucleation of new actin filaments, which is essential for processes such as cell motility and cell shape changes.

Function

The Arp2/3 complex, with ARPC1B as one of its subunits, is a key regulator of actin dynamics in cells. It promotes the formation of branched actin filaments, which are necessary for processes like cell migration, endocytosis, and cytokinesis. ARPC1B helps to nucleate actin filaments at the leading edge of migrating cells, facilitating their movement.

Clinical Significance

Mutations in the ARPC1B gene have been associated with a rare immunodeficiency disorder known as ARPC1B deficiency. This condition impairs the function of the Arp2/3 complex, leading to defects in immune cell migration and function. Patients with ARPC1B deficiency may experience recurrent infections and other immune-related complications.