AZD4831

From WikiMD's Wellness Encyclopedia

AZD4831 is a pharmaceutical compound currently under investigation for its potential therapeutic effects. It is being developed by AstraZeneca, a global biopharmaceutical company. AZD4831 is primarily being studied for its role in treating heart failure with preserved ejection fraction (HFpEF).

Mechanism of Action[edit | edit source]

AZD4831 is a selective myeloperoxidase (MPO) inhibitor. Myeloperoxidase is an enzyme that is involved in the production of reactive oxygen species (ROS) and is implicated in various inflammatory processes. By inhibiting MPO, AZD4831 aims to reduce oxidative stress and inflammation, which are key contributors to the pathophysiology of HFpEF.

Clinical Trials[edit | edit source]

AZD4831 is currently undergoing clinical trials to evaluate its safety, tolerability, and efficacy. These trials are essential to determine the potential benefits and risks associated with the drug. The clinical trials are conducted in multiple phases, starting with Phase I to assess safety in healthy volunteers, followed by Phase II and III to evaluate efficacy and safety in patients with HFpEF.

Potential Benefits[edit | edit source]

The inhibition of MPO by AZD4831 could lead to several potential benefits for patients with HFpEF, including:

  • Reduction in oxidative stress
  • Decrease in inflammation
  • Improvement in cardiac function
  • Alleviation of symptoms associated with heart failure

Side Effects[edit | edit source]

As with any investigational drug, AZD4831 may have side effects. The clinical trials aim to identify and monitor these side effects to ensure the safety of the patients. Common side effects observed in early trials include nausea, headache, and fatigue.

Related Compounds[edit | edit source]

AZD4831 is part of a broader class of MPO inhibitors being explored for various inflammatory and cardiovascular conditions. Other related compounds include:

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD