Ablukast
Overview[edit | edit source]
Ablukast is a leukotriene receptor antagonist used in the management of asthma and allergic rhinitis. It functions by blocking the action of leukotrienes, which are inflammatory chemicals the body releases after coming in contact with an allergen or irritant. By inhibiting these chemicals, Ablukast helps to reduce inflammation, bronchoconstriction, and mucus production in the airways.
Mechanism of Action[edit | edit source]
Ablukast works by selectively binding to cysteinyl leukotriene receptors (CysLT1) in the respiratory tract. Leukotrienes are derived from arachidonic acid and are potent mediators of inflammation. By blocking these receptors, Ablukast prevents leukotrienes from exerting their effects, which include bronchoconstriction, increased vascular permeability, and recruitment of inflammatory cells.
Clinical Uses[edit | edit source]
Ablukast is primarily used in the treatment of chronic asthma. It is not intended for the relief of acute asthma attacks but is used as a maintenance therapy to prevent symptoms. Additionally, Ablukast is effective in treating symptoms of allergic rhinitis, such as nasal congestion, sneezing, and runny nose.
Administration and Dosage[edit | edit source]
Ablukast is administered orally, typically in the form of tablets. The dosage may vary depending on the age of the patient and the severity of the condition being treated. It is important for patients to follow their healthcare provider's instructions regarding dosage and administration.
Side Effects[edit | edit source]
Common side effects of Ablukast include headache, dizziness, and gastrointestinal disturbances such as nausea and diarrhea. In rare cases, patients may experience mood changes or allergic reactions. It is important for patients to report any unusual symptoms to their healthcare provider.
Contraindications and Precautions[edit | edit source]
Ablukast should be used with caution in patients with a history of liver disease, as it is metabolized by the liver. It is contraindicated in patients with known hypersensitivity to the drug or any of its components. Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.
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