Acute myeloid leukemia M7
Acute Myeloid Leukemia M7 Acute Myeloid Leukemia M7, also known as Acute Megakaryoblastic Leukemia (AMKL), is a rare subtype of acute myeloid leukemia characterized by the proliferation of megakaryoblasts. This condition is classified under the French-American-British (FAB) classification system as M7.
Clinical Presentation[edit | edit source]
Patients with Acute Myeloid Leukemia M7 often present with symptoms related to bone marrow failure, such as anemia, thrombocytopenia, and neutropenia. Common symptoms include fatigue, easy bruising or bleeding, and increased susceptibility to infections.
Diagnosis[edit | edit source]
The diagnosis of AMKL is confirmed through a combination of morphological, immunophenotypic, and genetic studies. Bone marrow aspiration and biopsy are essential for diagnosis, revealing a high percentage of megakaryoblasts.
Morphology[edit | edit source]
Megakaryoblasts in AMKL are typically medium to large in size with basophilic cytoplasm and may show cytoplasmic blebbing.
Immunophenotyping[edit | edit source]
Immunophenotyping by flow cytometry is crucial for diagnosis. Megakaryoblasts express platelet glycoproteins such as CD41, CD42b, and CD61.
Cytogenetics[edit | edit source]
Cytogenetic analysis often reveals specific chromosomal abnormalities, such as t(1;22)(p13;q13) in infants or complex karyotypes in older patients.
Treatment[edit | edit source]
The treatment of AMKL involves intensive chemotherapy regimens similar to those used for other subtypes of acute myeloid leukemia. In some cases, hematopoietic stem cell transplantation may be considered, especially in patients with high-risk features.
Prognosis[edit | edit source]
The prognosis of AMKL varies depending on age, genetic abnormalities, and response to treatment. Infants with t(1;22) have a distinct clinical course and may have a better prognosis with appropriate therapy.
Epidemiology[edit | edit source]
AMKL is a rare form of leukemia, accounting for approximately 1-2% of all cases of acute myeloid leukemia. It is more common in children, particularly those with Down syndrome.
See Also[edit | edit source]
External Links[edit | edit source]
- [National Cancer Institute - Acute Myeloid Leukemia](https://www.cancer.gov/types/leukemia/patient/adult-aml-treatment-pdq)
- [Leukemia & Lymphoma Society](https://www.lls.org/leukemia/acute-myeloid-leukemia)
NIH genetic and rare disease info[edit source]
Acute myeloid leukemia M7 is a rare disease.
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Contributors: Prab R. Tumpati, MD
