Adaptogen

Adaptogen is a term used in herbal medicine to describe substances that are believed to increase the body's ability to resist the damaging effects of stress and promote or restore normal physiological functioning. The concept of adaptogens was originally created in 1947 to describe a substance that may increase resistance to stress.

History

The term "adaptogen" was first defined by Russian scientist Dr. Nikolai Lazarev in 1947. He described adaptogens as agents that help an organism to counteract any adverse effects of a physical, chemical or biological stressor by generating nonspecific resistance. Later, in 1968, Dr. Israel Brekhman, another Russian scientist, and Dr. I.V. Darymovhe expanded the definition of adaptogens to include substances that have a normalizing effect on physiology, irrespective of the nature of the pathological state.

Mechanism of action

Adaptogens work at a molecular level by regulating a stable balance in the hypothalamic-pituitary-adrenal axis (HPA axis). They interact with the neuroendocrine system, particularly hormones, and the immune system. Adaptogens have a broad action on the body and can increase the body's ability to resist multiple stressors.

Examples of adaptogens

Some examples of adaptogens include Panax ginseng, Ashwagandha, Rhodiola rosea, Schisandra, and Holy Basil. These herbs are often used in traditional medicine practices like Ayurveda and Traditional Chinese Medicine.

Research and evidence

While there is some scientific evidence that suggests these substances can be helpful in treating stress and anxiety, more research is needed to fully understand their mechanisms and potential benefits. Some studies have shown that adaptogens can have anti-fatigue, anti-stress, and anti-depressive effects, but these studies are often small and not well-controlled.

Safety and side effects

Most adaptogens are considered safe for most people. However, they can have side effects and interact with medications. It's important to talk to a healthcare provider before starting any new supplement regimen, especially if you have a medical condition or are taking other medications.

See also

• Herbal medicine
• Stress (biology)
• Ayurveda
• Traditional Chinese Medicine