Adermatoglyphia

A rare genetic disorder affecting fingerprints

Adermatoglyphia

Diagram of autosomal dominant inheritance

Adermatoglyphia is a rare genetic disorder characterized by the absence of dermatoglyphics, which are the ridges on the skin of the fingers, palms, toes, and soles. This condition is often referred to as "immigration delay disease" because individuals with adermatoglyphia lack fingerprints, which can complicate identity verification processes.

Genetics

Adermatoglyphia is inherited in an autosomal dominant pattern, meaning that a single copy of the altered gene in each cell is sufficient to cause the disorder. The condition is associated with mutations in the SMARCAD1 gene, which plays a role in the development of skin ridges during embryonic development.

Clinical Features

Individuals with adermatoglyphia typically have:

• Absence of fingerprints
• Normal sweat gland function
• No other significant skin abnormalities

The lack of fingerprints is the primary clinical feature, and there are usually no other health issues associated with the condition.

Diagnosis

Diagnosis of adermatoglyphia is primarily based on the clinical observation of absent fingerprints. Genetic testing can confirm the presence of mutations in the SMARCAD1 gene. Family history can also provide clues, as the condition is inherited in an autosomal dominant manner.

Management

There is no treatment required for adermatoglyphia, as it does not cause any health problems. Management focuses on addressing the practical issues related to the absence of fingerprints, such as difficulties with biometric identification.

Related pages

• Dermatoglyphics
• Genetic disorder
• Autosomal dominant